HARMONY: Data-enabled, shared fluid management platform in haemodialysis

Fluid status in haemodialysis is strongly associated with acute symptoms, hospitalization and cardiovascular mortality. Despite technological advances, routine fluid management practice (target weight estimation; interdialytic weight gain control) have changed little in decades. Our consortium frames fluid management as a complex intervention requiring systems level support that integrates routinely collected dialysis data with patient reported symptoms to enable truly shared, patient centered decisions. A transnational approach (Ireland, Scotland, Austria) enhances generalizability and device agnostic implementation. The intervention design is under-pinned by behavioral theory, drawing specifically on Social Cognitive Theory and established behavior-change mechanisms related to self-efficacy, feedback, and shared decision-making.

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Different studies:

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Pathophysiological studies:

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Letters and commentaries:

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Reviews:

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Consensus meeting:

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GRANTS

2008 - 2010

Treat-to-target trial of basal insulin in post-transplant hyperglycemia (TIP): efficacy and safety of a novel protocol in renal transplant recipients receiving a tacrolimus-based immunosuppression.

  • Proposal written by: Manfred Hecking
  • Amount granted: € 49.500
2009 - 2010

Transplant-Associated Hyperglycemia (TAHG): An Exploratory Study.

  • Proposal written by: Manfred Hecking
  • Amount granted: € 7.200,–
2010 - 2020

Insulin Therapy for the Prevention of New-Onset Diabetes after Transplantation (ITP-NODAT).

  • Proposal written by: Manfred Hecking, Marcus Säemann
  • Amounts granted: € 311.012
2012 - 2020

Sensor-Augmented Insulin Pump Therapy against Post-transplant Hyperglycemia: A Semi-Closed Loop System to Prevent New-Onset Diabetes after Renal Transplantation.

  • Proposal written by: Manfred Hecking, Johannes Werzowa, Marcus Säemann
  • Amount granted: € 35.000,–
Supporters:

THE PROJECT TEAM

Manfred Hecking, MD, PhD
Manfred Hecking, MD, PhD

Clinical Nephrologist, Senior Physician, Group Leader

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Sebastian Mussnig, MD, PhD
Sebastian Mussnig, MD, PhD

Assistant Physician, Clinical Study Lead

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Janosch Niknam, MD
Janosch Niknam, MD

Clinical Researcher

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